The KINSHIP-DCM study is a clinical research study of the investigational drug, danicamtiv, for people with symptomatic genetic or familial dilated cardiomyopathy. An investigational drug has not been approved by regulatory authorities like the US Food and Drug Administration (FDA) or European Medicines Agency (EMA), and it can only be used in clinical research studies like the KINSHIP-DCM Study.
The study will evaluate danicamtiv’s safety and efficacy to determine whether it can improve heart function and quality of life in people with symptomatic genetic or familial DCM.
You may be able to join the study if you meet the following requirements:
Must be 18 years or older
Confirmed diagnosis of genetic or familial DCM
DCM symptoms that affect your daily life
This list is not exhaustive and other study requirements will apply.
Participation in KINSHIP-DCM lasts about 36 Weeks and consists of approximately 9 in-clinic visits. Travel assistance may be provided. The KINSHIP-DCM study is a randomized, placebo-controlled trial. That means participants are assigned by chance, like flipping a coin, to receive either danicamtiv or a placebo (a pill with no active medicine). This helps researchers compare results and understand how well the investigational drug may work.
Study participants can expect the following:
Participation in a clinical study is voluntary. We encourage you to ask any questions you have. You may leave the study at any time, for any reason.
Contact a study clinic near you!
Contact a Study ClinicDanicamtiv is an investigational drug that is designed to help the heart pump more effectively which may improve cardiac function. In turn this may reduce symptoms like shortness of breath, fatigue and exercise intolerance for people with genetic or familial DCM.
If you join the study, you will be randomly assigned to take danicamtiv or placebo (sugar pill), twice a day for up to 28 weeks.
DCM is a condition in which the heart muscle weakens and enlarges, making it harder for the heart to pump blood. Genetic and familial DCM are two forms of DCM that can be passed down through families. Some people with genetic or familial DCM may have symptoms.
There are currently no approved medications that address the root cause of genetic or familial DCM.
Some possible symptoms:
Here are some common questions and answers about study participation.
Clinical research studies, or trials, help scientists and doctors explore whether a medical strategy, device, or medication is safe and effective for people. Before any medication can be approved and made available to the public, it must go through several phases of clinical research.
Before enrolling in a clinical trial, you must sign an Informed Consent Form (ICF). The ICF contains information about the study, including study goals, how long the study will last, benefits and risks, and the tests and procedures you will undergo.
Study participation usually involves visiting a clinic regularly, taking or receiving an investigational medicine or a placebo (sugar pill), and having assessments to monitor your health. You can continue to see your regular doctor (cardiologist), but you should let them know that you are participating in a study.
Participation in a clinical research study is your choice. It will not impact the care you are currently receiving from your cardiologist, and you may stop at any time.
If you have additional questions about participating in a clinical trial, contact a study clinic near you.
Use the filters, map, and listing to find the study clinic closest to you. Contact a study clinic to learn more.